"This idea that unless you are suffering, grinding, working every hour of every day, you're not working hard enough.
"It's such bulls**t, such utter bulls**t. It has deleterious effects not just on your business but on your wellbeing."
Ohanian, who co-founded the social news website known as the "front page of the internet" in 2005 with fellow University of Virginia graduate Steve Huffman when both men were just 22, now has an estimated net worth of US$9 million ($13.3m).
But earlier this year, Ohanian described how he threw himself into work during the early days of Reddit as a coping mechanism after developing depression after his former girlfriend was seriously injured in an accident, and after he lost his mother to brain cancer.
Writing in medium.com, he said becoming a workaholic was not a healthy solution.
"As entrepreneurs, we are all so busy 'crushing it' that physical health, let alone mental health, is an afterthought for most founders," Ohanian wrote.
"It took me years to realise that the way I was feeling — when working on Reddit was the only therapy I had — was depression.
"I haven't felt it in a long time and I'm grateful for it, but it doesn't take losing a loved one to feel this way, especially with the pressures of entrepreneurship.
"When you're struggling, talk to someone. It can be a professional, a family member, or even a stranger can be helpful in getting you into a better headspace."
He wrapped up his speech at the summit by pleading with the audience not to "succumb to hustle porn".
Ohanian tied the knot with tennis champ Serena Williams on November 16, 2017 — on his late mother's birthday.
The couple's daughter, Alexis Olympia Ohanian Jr, was born two months before the wedding, on September 1.
Ohanian and Huffman sold Reddit to Condé Nast in 2006, making the then 23-year-olds instant multi-millionaires.
While the exact sale price has never been revealed, it has been estimated to be between US$10-20m.
