Gruenenthal's lawyers rejected the compensation demand, saying the case had exceeded the statute of limitations. The German firm's representative in Spain, Guillermo Castillo, also insisted that thalidomide was withdrawn from the country in December 1961, as it was elsewhere in Europe.
The court further heard that Gruenenthal offered a total 120,000 euros in compensation to Spanish victims some years ago an offer that was rejected.
More than 30 Spaniards bearing the effects of the drug attended the one-day trial.
"Us being alive is the best evidence, because many (victims) have already died," said Matilde Roman, 52, whose right arm was severely deformed at birth. "My mother took thalidomide, but she was illiterate and nobody explained to her the damage of this medication."
The amount being demanded as compensation is based on multiplying 20,000 euros by the level of disability per plaintiff, which is measured in percentage points. A ruling in the case is expected within a month.