Opposite the brothel entrance, in the dockside area of the city, Schipperskwartier, is a police station. Each room has panic buttons in case clients turn violent.
A doctor is just around the corner and, because of the biometric keypad, there is no sub-letting of any of the 51 rooms to unauthorised prostitutes.
No one here is a victim of people-traffickers and only women with EU passports can work from Villa Tinto.
"It's safer, it's more open," says Mr Vos, "there is no exploitation because the girls are free to come and work when they want. Everything is controlled."
Yet the creation of such brothels has polarised the debate in Europe over how to deal with prostitution: should it be gentrified or should those who seek to buy sex be criminalised?
In Paris recently the Parliamentary Assembly of the Council of Europe discussed the continent's different approaches to dealing with the sex trade. Meanwhile women's groups have stepped up their opposition to new experiments in tolerance.
But in Antwerp itself Villa Tinto is deemed such a success that it features in the political campaign ahead of forthcoming municipal elections.
For several centuries prostitution has been centred in the port district of Antwerp but, over the last few years, it has been concentrated into just three streets.
Outside Villa Tinto the socialist mayor of Antwerp, Patrick Janssens, is trailed by TV cameras as he extols the virtues of a policy which, he says, has revived large chunks of the city.
Mr Janssens says: "The fact that we have concentrated prostitution into three streets means that we can put in place tough criteria. Most of these people are working in extremely good conditions. It was not like this five years ago. Now we have been able to create a situation where women are more independent, they are very safe to the extent that the individual prostitute has to provide her fingerprint when she rents the room."
Antwerp is increasingly a model for Belgian cities and, potentially for others in Europe. Delegations have visited from Brussels, Charleroi and Liege.
Villa Tinto is trying to open another brothel in Barcelona.
Mr Janssens says that five years ago he would not have felt safe walking the streets of this part of the city. Now he recommends a tour of these three streets to out of town visitors.
With its designer credentials and reputation as a super-brothel, Villa Tinto attracts a mix of tourists and punters from across the social spectrum.
According to Mr Vos "it has all types of clients, ranging from 'the normal guy working in the street' to lawyers and doctors.
Built around a courtyard it looks from the outside like a seedy suburban shopping arcade.
Because of the tight controls, the area of the city blighted by the sex industry is receding, cut from about 17 streets to three. Nearby buildings outside the tolerance zone are being refurbished for residential housing.
Meanwhile the authorities say that controlling prostitution in this small area means that they can concentrate on tough policing of the worst aspects of the sex business. According to the city authorities the tough line on street prostitution only works because of the tolerant approach in the three streets in Schipperskwartier.
"I don't think it is realistic to have zero tolerance," says Mr Janssens. "What we have tried to do is to make it a civilised profession."
That, however, is anathema to those who believe that the sex business can never be civilised.
Mary McPhail, Secretary General of the European Women's Lobby, argues that a better answer to the problem is the criminalisation of all those seeking to use prostitutes.
She argues: "If such a showcase of elite brothels [like Villa Tinto] did emerge it would be no more than a front for what most people experience which is intimidation and violence," she argues. "We believe that it is a criminal activity for one person to seek to buy access to another's body through prostitution."
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