"We've been in the luxury market for 14 years, but this reaches a wider audience ... [it's] a totally different price point, a totally different product and it's really our first time in the States going en masse."
Landing in stores for the American summer, the deal has a retail value of around US$4 million ($5 million) a year, according to Walker.
The move mimics her trajectory across the Tasman, where in 2008 she teamed up with department chain Myer for her Hi There range after more than 10 years of selling in high-end Australian shops. It has since become one of Myer's most profitable pieces of business.
Walker says her Australian manufacturer will end up doing a "lot of the leg work" in the set-up with Anthropologie.
"It just fits in beautifully with our existing infrastructure. It goes straight through our manufacturer in Melbourne ... they kind of do all the hard work and we get to do the fun."
For Walker, the attraction of Hi There - a collection of "cute dresses, fun prints, and strong colours" - is a no-brainer.
"All retailers around the world want that sweet product that they know is going to work.
"There is no room for risk-taking right now, everybody's pulled back on that and I think that's one of the reasons why it does so well with Myer and why Anthropologie were attracted to it."
Walker says retailers are after products at different price points because customers do not shop "head-to-toe" in Chanel.
"They mix it up with a little bit of Topshop, a little bit of vintage and a little bit of designer."
Furthermore, offering a range of products at different prices is a way retail can weather tight times.
"For smart retailers, we make sure there is something there that the market is demanding ... you can come into a Karen Walker store and buy something for $15 or $15,000or anywhere in between and Ithink that's what makes exciting retail."
The Karen Walker brand extends into jewellery, eyewear, fragrances and, surprisingly, a range of house paints.
Diversifying the product line is a central part of Walker's business plan. She says offering "more than just a rack of clothes" gives customers a far richer shopping experience.
And the next Karen Walker product in the pipeline?
"The next is homeware, which is also a partnership with Myer. Their homeware division came to us and said, 'We've seen how well Hi There is doing ... we want that same look, feel, attention to print and colour and that fun happy product. We want it in beach towels and sheets and cups."'