In January, GE revealed that the Securities and Exchange Commission was investigating the company over a US$15 billion ($21.7b) hit taken to cover miscalculations made within an insurance unit.
The company's woes have hammered its stock in recent years.
GE shares closed at US$12.95 Tuesday, down 78 per cent from their high of US$60 a share in August 2000. The decline has also been steep more recently. The shares are down more than 60 per cent from their most recent peak in July 2016. The stock is down 26 per cent so far this year.
The stock-price slide is a key factor in GE's exit from the Dow, which is calculated using the prices of 30 large, or "blue chip" stocks from various US industries.
The low price of GE shares means the company has a weight in the index of less than one-half of one percentage point, S&P Dow Jones Indices said.
Walgreens Boots Alliance's share price is higher, and it will contribute more meaningfully to the index.
The move to drop General Electric Co. from the Dow also reflects how industrial companies are playing a less prominent role in the US economy than technology, finance, health care and consumer companies, such as Walgreens.
"Today's change to the DJIA will make the index a better measure of the economy and the stock market," said David Blitzer, managing director and chairman of the index committee at S&P Dow Jones Indices.
Tuesday's announcement added to GE's stock woes. It came after the close of trading on Wall Street, but in after-market dealings, GE's shares fell 1.4 per cent. Those of Deerfield, Illinois-based Walgreens Boots Alliance Inc., meanwhile, jumped 3.2 per cent.
- AP