"The market is processing what appears to be a slow grind to military action against Syria," said John Kilduff, a partner at Again Capital, a New York hedge fund that focuses on energy, told Bloomberg News.
Concern about Syria took away from the economic data supporting the view of a sustained pick-up in the US recovery.
The Institute for Supply Management's index rose to 55.7 in August, the strongest since June 2011, and up from 55.4 in July.
Separately, Markit's final US Manufacturing Purchasing Managers Index fell to 53.1 last month, from 53.7 in July, and down from an earlier flash estimate of 53.9. Still, new orders increased at a solid pace, Markit said.
"The downturn in the headline PMI is a disappointment, suggesting that there is a risk that the goods-producing sector is stalling. However, a more encouraging picture emerges if we look at the details," Chris Williamson, chief economist at Markit, said in a statement. "In particular, inflows of new orders-a useful guide to future production-are growing at the fastest rate for seven months."
Shares of Microsoft fell, last down 5 per cent and the biggest drag on the Dow, after it agreed to buy Nokia's mobile-phone business for US$7.2 billion. Shares of Verizon Communications retreated, last down 2.7 per cent and the second-largest drag on the Dow, on its deal to buy Vodafone's 45 per cent stake in Verizon Wireless for US$130 billion
In Europe, the Stoxx 600 Index fell 0.4 per cent from the previous close. The UK's FTSE 100 Index dropped 0.6 per cent, while Germany's DAX and France's CAC 40 both fell 0.8 per cent.