The Fed also on Wednesday confirmed it will wind down its bond-buying programme so that the purchases end in early March.
The Fed's move towards tighter monetary policy comes during a period of extreme volatility for financial markets with US stocks whipsawing in recent days as investors rush to position themselves for a more hawkish stance from the central bank.
In the weeks leading up to the January meeting, several Fed officials signalled their support for "lift-off" in March, citing underlying strength in the US labour market and inflation that is running at its fastest pace in roughly four decades.
The FOMC and other regional branch presidents last month pencilled in three quarter-point increases in 2022, with three more in 2023 and another two in 2024. At the time, they forecast core inflation to moderate to 2.7 per cent by the end of the year from the current level of 4.7 per cent, and the unemployment rate to fall to 3.5 per cent.
However, in recent weeks Fed officials and Wall Street economists have said a more aggressive rate rising cycle may be warranted with four or more increases this year. If inflation does not ease, it could result in interest rate increases in March and at each of the subsequent six meetings this year, some economists say.
Debate is also under way about how the Fed will shrink its roughly $9tn balance sheet, after policymakers held their first substantive discussions on the central bank's holdings last month.
The Fed held further deliberations at this week's meeting, releasing a set of principles on its approach to shrinking the size of its balance sheet.
No decision has been made about how rapid the reduction will be or when it may begin, but officials agreed it would occur in a "predictable manner".
They had previously agreed that the "run off" should proceed more quickly than its attempt to pare back holdings in 2017, when the balance sheet hovered at about $3.7tn.
The 2017 episode ended in acute financial market stress — with short-term borrowing costs spiking as it became evident that too much cash had been drained from the financial system.
Economists broadly expect the next run-off to begin in July, with some suggesting an earlier start. The statement said the process would begin after interest rates have begun to rise.