With its new purchases of long-term Treasurys, the Fed's investment portfolio, which is nearly $3 trillion, would swell to nearly $4 trillion by the end of 2013 if its bond purchase programs remain in place.
All told, the policies are intended to help an economy that the Fed says is growing only modestly with 7.7 per cent unemployment in November.
Stocks and bond yields rose after the Fed's statement was released. The Dow Jones industrial average was little changed just before the Fed news and jumped 69 points shortly after.
The yield on the benchmark 10-year Treasury note rose to 1.69 per cent from 1.65 per cent as investors sold ultra-safe investments and moved money into stocks.
"The Fed is aggressively trying to add to the economy's strength," said Jim O'Sullivan, chief economist at High Frequency Economics.
The Fed said it will continue the bond purchases until the job market improves substantially. It said it can pursue the aggressive stimulus programs because inflation remains below its target.
The statement was approved on an 11-1 vote. Jeffrey Lacker, president of Federal Reserve Bank of Richmond, objected for the eighth time this year.
The meeting was held against the backdrop of the looming "fiscal cliff," the sharp tax increases and spending cuts that will hit the economy in January if Congress and President Barack Obama are unable to reach an agreement this month to avert them.
Bernanke has said that the Fed's efforts will not be able to rescue the economy if the budget negotiations fail and the country does go over the fiscal cliff.
Fears of the cliff have led some US companies to delay expanding, investing and hiring. Manufacturing has slumped. Consumers have cut back on spending. Unemployment remains elevated. If higher taxes and government spending cuts were to last for much of 2013, most experts say the economy would sink into another recession.
The latest bond-buying program would replace an expiring program called Operation Twist. With Twist, the Fed sold $45 billion a month in short-term Treasurys and used the proceeds to buy the same amount in longer-term Treasurys.
Twist didn't expand the Fed's investment portfolio, it just reshuffled the holdings. But the Fed has run out of short-term securities to sell. So to maintain its pace of long-term Treasury purchases and to keep long-term rates low, it must spend more and increase its portfolio.
The Fed's portfolio totals nearly $2.9 trillion more than three times its size before the 2008 financial crisis.
The Fed has launched three rounds of bond purchases since the financial crisis hit. In announcing a third program in September, the Fed said it would keep buying mortgage bonds until the job market improved substantially.
Skeptics note that rates on mortgages and many other loans are already at or near all-time lows. So any further declines in rates engineered by the Fed might offer little economic benefit.
Inside and outside the Fed, a debate has raged over whether the Fed's actions have helped support the economy over the past four years, whether they will ignite inflation later and whether they should be extended.