The taskforce - to be led directly by the ATO commissioner and staffed by 1,300 tax office workers, will pursue cases of deliberate tax avoidance and evasion.
The government will also beef up its Multinational Tax Avoidance Law (MAAL), which came into effect on January 1, with a new diverted profits tax to impose a 40 per cent penalty tax rate on multinationals attempting to shift their Australian profits offshore.
The new tax is based on Britain's "Google tax" which targets multinationals that avoid paying tax by shifting profits to lower taxing countries.
In Australia, corporate giants including BHP Billiton, Rio Tinto, Apple and Google have been identified as using so-called marketing hubs in Singapore to help reduce their tax bill in the country.
"Everyone has to pay their fair share of tax, especially large corporates and multinationals, on what they earn here in Australia," Treasurer Scott Morrison said.
The new tax, in conjunction with MAAL, could raise up to $650 million over four years from large multinationals. The tax avoidance taskforce, in turn, is expected to raise more than $3.7 billion.
"The message tonight is that Australia now has a whole package of weapons to tackle tax avoidance by large corporates," said David Watkins, tax partner at advisory firm Deloitte. "I can't think of many other countries that have similar measures."
Other measures include putting in place new rules by January 1, 2018 to close loopholes allowing multinationals to exploit differences in tax treatment across different countries. The government will also update laws to close loopholes for related-party transactions to shift profits overseas and reduce tax paid in Australia.
And whistleblowers who help expose companies and individuals trying to dodge the tax man will be given increased protection.
Multinational tax avoidance has been the subject of heated public debate over the past year as global mining and tech giants come under the ATO's radar over the use of various structures to avoid paying taxes in Australia.
"The belief is there is still a lot of income tax revenue that can be recovered," Tax Institute President Arthur Athanasiou said.
"The new rules suggest Australian taxpayers have had enough of companies trying to avoid paying their fair share of taxes."
- AAP