A disappointing result from Apple dragged shares of the technology giant lower, weighing on the overall mood.
Apple dropped more than 5 per cent after profit fell short of expectations. It sold fewer iPhones than expected, as consumers opted to wait for the new 4S model.
"The market was expecting very strong iPhone sales going into the product launch," Giri Cherukuri, head trader at Oakbrook Investments, which holds Apple shares, told Bloomberg News. "It stands to reason that a lot of people were waiting for the new iPhone to come out."
Pacing losses on Wall Street were Federal Reserve comments, made in its Beige Book survey, about the lacklustre economic outlook.
"Overall economic activity continued to expand in September, although many Districts described the pace of growth as "modest" or "slight" and contacts generally noted weaker or less certain outlooks for business conditions," the Fed said.