The Dow slid as declines in shares of Verizon and those of Microsoft, recently down 1.7 per cent and 1.3 per cent respectively, outweighed gains in shares of JPMorgan Chase and those of Home Depot, recently up 1.3 per cent and 1 per cent respectively.
Shares of Alphabet, the parent of Google, slid after the European Union antitrust regulator slapped Google with a record US$2.7 billion fine for manipulating search results to favour some of its own services over those of rivals.
"Just being put on notice can limit Google's strategic options into the future," Matti Littunen, a digital media and online advertising analyst with Enders Analysis in London, told Reuters.
Indeed, complying might be the challenge.
The EU order "seems to be quite simple but is actually quite complicated in the sense that they leave it to Google to come up with a solution," Ben Van Rompuy, a lecturer at Leiden University in the Netherlands, told Bloomberg.
In Europe, the Stoxx 600 Index ended the session with a 0.8 percent drop from the previous close.
European Central Bank President Mario Draghi signalled the central bank might ease its monetary stimulus.
"All the signs now point to a strengthening and broadening recovery in the euro area," Draghi told the ECB Forum on Central Banking in Sintra, Portugal. "Deflationary forces have been replaced by reflationary ones."
"As the economy continues to recover, a constant policy stance will become more accommodative, and the central bank can accompany the recovery by adjusting the parameters of its policy instruments-not in order to tighten the policy stance, but to keep it broadly unchanged," Draghi noted.
The UK's FTSE 100 Index slipped 0.2 per cent, while France's CAC40 Index declined 0.7 per cent, and Germany's DAX Index fell 0.8 per cent.
Euro-zone bonds also declined, while the euro strengthened against the greenback.
Draghi "offered the first inclination that central bank stimulus could soon be wound in," Jasper Lawler, a market analyst at London Capital Group, wrote in a note, Bloomberg reported. "The notable switch in Draghi's speech was using 'transitory' to describe global factors that have been pulling inflation lower."