Wall Street declined as investors geared up for a speech by Federal Reserve Chair Janet Yellen later in the day and US President-elect Donald Trump's inauguration on Friday.
Across the Atlantic, European Central Bank policy makers kept key interest rates and asset purchase program unchanged. President Mario Draghi told reporters that underlying inflation pressures remain subdued, flagging the central bank's commitment to ongoing stimulus.
The latest US economic reports offered better-than-expected labour and housing market data, bolstering the greenback and sending Treasuries lower.
A Labour Department report showed jobless claims fell by 15,000 to 234,000 in the week ended January 14. Separately, a Commerce Department report showed that US housing starts rose a higher-than-expected 11.3 per cent in December to a 1.23 million annualised rate.
"It's fair to say, the economy is near maximum employment and inflation is moving toward our goal," Yellen told the Commonwealth Club of California in San Francisco on Wednesday.