"There's been a lot of optimism regarding the Trump administration so this could very well be the first setback," Erik Davidson, chief investment officer at Wells Fargo Private Bank in San Francisco, told Reuters.
"What the market wants is to get through the healthcare question so that we can move on to tax reform."
The Dow moved higher as gains in shares of Nike and those of Goldman Sachs, up 2.6 per cent and 1.3 per cent respectively, outweighed declines in shares of Intel and those of UnitedHealth Group, down 0.4 per cent and 0.3 per cent respectively.
The latest US data underpinned an optimistic outlook for the economy. A Commerce Department report showed new home sales climbed a higher-than-anticipated 6.1 per cent to a seasonally adjusted annual rate of 592,000 units in February.
A Labour Department report showed initial claims for state unemployment benefits rose 15,000 to a seasonally adjusted 258,000 for the week ended March 18.
"Rising mortgage rates don't appear to have been much of an impediment to increasing housing demand in February as solid job gains, faster wage growth, and stronger household formations offset the drop in affordability," David Berson, chief economist at Nationwide in Columbus, Ohio, told Reuters.
In Europe, the Stoxx 600 Index finished the day with a 0.4 per cent drop from the previous close. The UK's FTSE 100 Index rose 0.2 per cent, France's CAC 40 Index climbed 0.8 per cent, while Germany's DAX Index rallied 1.1 per cent.
Amid a food safety scandal that has prompted bans on Brazilian meat exports, JBS and BRF are pressing ahead with plans to list overseas units while seeking to shore up investor confidence with a campaign, arguing the country's police probe into alleged bribery of health officials to overlook food safety breaches misstated facts, Reuters reported, citing four people involved in the deals.
JBS, the world's biggest meatpacker, has no intention to delay the US$1 billion (NZ$1.4 billion) initial public offering of JBS Foods International in New York, which it hopes to finalise in May or June, one of the people said, according to Reuters.
BRF, the largest poultry producer, continues to analyse selling a US$1.5 billion (NZ$2.1 billion) stake in One Foods Holdings, its halal meats unit, through a London IPO or a private placement, another person said, Reuters reported.
Neither firm has seen a pushback from potential investors, said the people, who spoke under the condition of anonymity, because of the sensitivity of the matter, according to Reuters. JBS and BRF, both based in São Paulo, declined to comment.