The Dow moved higher as gains in shares of Caterpillar and those of JPMorgan Chase, recently up 2.2 per cent and 2 per cent respectively, outweighed slides in shares of Johnson & Johnson and those of General Electric, recently down 1 per cent and 0.3 per cent respectively.
"The market has had trouble really appreciating, but it has had even more trouble declining," Rick Meckler, president of LibertyView Capital Management in Jersey City, New Jersey, told Reuters.
"It seems like any negative period is very quickly met with new buyers."
"Interest rates are still very low and a lot of investors see little opportunity to invest anywhere but in stocks," according to Meckler.
The latest corporate earnings also offered support. Shares of Monsanto rose, trading 1.1 per cent higher as of 2.12pm in New York, after the company that's being bought by Germany's Bayer reported quarterly earnings that beat expectations, bolstered by continued momentum in soybean technologies.
"In soybeans, Monsanto has seen strong demand for the latest technologies, with growth of approximately 30 per cent in global gross profit now expected for fiscal year 2017," the company said in a statement.
Monsanto upgraded its full-year gross profit outlook for its seed and genomics unit. "There was a lot of acreage that rotated out of corn and into soy and Monsanto was set up really well for that since they had some product launches in soy this year," Matt Arnold, an analyst with Edward Jones, told Reuters.
Shares of General Mills also gained, trading 1.9 per cent higher as of 3.15pm in New York, after the maker of cereal reported quarterly profit that bettered expectations.
In Europe, the Stoxx 600 Index ended the session at 385.82, little changed from the previous close, and reversing a decline of as much as 1 per cent earlier in the day.
Draghi's speech at the ECB Forum in Sintra, Portugal, on Tuesday was intended to strike a balance between recognising the currency bloc's economic strength and warning that monetary support is still needed, Bloomberg reported, citing three Eurosystem officials familiar with policy makers' thinking. The officials spoke separately and asked not to be named as internal discussions are confidential, Bloomberg reported.
France's CAC40 Index slipped 0.1 per cent, and Germany's DAX Index declined 0.2 per cent, while the UK's FTSE 100 Index dropped 0.6 per cent, as Burberry Group shares shed 3.5 per cent.
The UK's Investment Association, which advises fund managers, joined a chorus of critics and has issued an alert about Burberry, Bloomberg reported, citing a person familiar with the issue.
It focuses on awards to Chief Executive Officer Christopher Bailey and Chief Financial Officer Julie Brown, as well as performance conditions attached to the long-term incentive plan, the person said, according to Bloomberg.