The Dow weakened as slides in shares of Wal-Mart and those of Intel, recently down 1.5 per cent and 1 per cent respectively, outweighed gains in shares of Boeing and those of Coca-Cola, up 0.8 per cent and 0.7 per cent respectively.
Shares of Target sank, trading 12.3 per cent lower as of 1.12pm in New York, after the retailer missed the mark with its full-year profit forecast and unexpectedly announced plans to lower its prices.
"Our fourth quarter results reflect the impact of rapidly-changing consumer behaviour, which drove very strong digital growth but unexpected softness in our stores," Brian Cornell, CEO of Target, said in a statement. "We will invest in lower gross margins to ensure we are clearly and competitively priced every day."
"While the transition to this new model will present headwinds to our sales and profit performance in the short term, we are confident that these changes will best-position Target for continued success over the long term," Cornell noted.
Investors weren't so sure and Target's results weighed on the industry.
"It's that drum beat of bad retail news of the big-box retailers," Mark Spellman, portfolio manager at Alpine Funds in Purchase, New York, told Reuters. "So in case you thought maybe that was over, Target certainly reminded us all that it didn't."
Bucking the trend, shares of Priceline jumped, up 6.3 per cent as of 1.19pm, after the company posted quarterly results that beat expectations.
The company reported "accelerating growth in hotel room nights booked, with solid organic growth and attractive profit margins," Priceline CEO Glenn Fogel said in a statement. "We also recorded accelerating growth in room nights booked for the full year 2016 over 2015."
In Europe, the Stoxx 600 Index ended the day with a gain of 0.2 per cent from the previous close.The UK's FTSE 100 Index gained 0.1 per cent, as did Germany's DAX Index, while France's CAC 40 Index increased 0.3 per cent.