In late trading in New York, the Dow Jones Industrial Average inched 0.06 per cent lower, while the Standard & Poor's 500 Index fell 0.09 per cent, and the Nasdaq Composite Index slipped 0.08 per cent.
Last trading at 18,088.57, the Dow is not far off its record high 18,288.63 reached earlier this year, while the S&P 500 is close too.
"When you have stocks at the high end of the historical range you need better news than what we have," Matt Maley, an equity strategist at Miller Tabak & Co in Newton, Massachusetts, told Bloomberg. "This rise in rates isn't coming from a better economy or a fundamental reason."
In the Dow, slides in shares of Intel and those of Merck, last down 1.2 per cent and 0.9 per cent respectively, offset gains in shares of Wal-Mart and those of Walt Disney, last up 1.1 per cent and 0.9 per cent respectively.
In the latest economic data, the National Federation of Independent Business said its small business optimism index rose 1.7 points to 96.9 in April, the biggest advance since December.
In a fresh corporate deal, shares of AOL jumped, last 18.4 per cent higher, after Verizon Communications said it agreed to buy the company in a deal worth US$4.4 billion. Shares of Verizon last traded 0.5 per cent lower.
"There's the question of whether there is truly an advantage in owning all of this themselves," Craig Moffett of media research firm MoffettNathanson, told Reuters. "They are getting a hodgepodge of ancillary assets that may be as much a distraction as a benefit."
In Europe, the Stoxx 600 Index finished the session with a 1.3 per cent drop from the previous close.
France's CAC 40 Index fell 1.1 per cent, the UK's FTSE 100 Index dropped 1.4 per cent, while Germany's DAX slid 1.7 per cent. Greece's ASE Index rose 1.4 per cent.