Will Chase, who starred in TV series Nashville, said sarcastically: 'I'd suck at botany. But as long as Wells Fargo can help me realize my dream...! Patronizing much?'
Paul Wesley, who stars in The Vampire Diaries, wrote: 'Missed my shot at becoming a real grown-up/botanist.'
Jeff Kready, who appeared in Broadway's Les Miserables, wrote on Twitter: 'Dear Wells Fargo: This ad stinks. Sincerely, An actor whose mortgage you hold #theatre #dance #grownupscanbeactors.'
Some even mocked the advert, noting that being a Broadway actor is actually more lucrative than being a botanist, with an average salary of $46,000, according to job site Indeed.com.
Chris McCarrell, who has also featured in the cast of Les Miserables, wrote: 'Whispers. We make more money than your botanistttttttttttt. Wells FarGoooooo... awayyyyyyy.'
Josh Groban, who stars in musical The Great Comet, wrote: 'Brb gonna take out a Wells Fargo loan to go write Botany: The Musical!'
Wells Fargo has since been forced to apologise after the public outcry that emerged following the campaign.
It wrote on Twitter: 'Wells Fargo is deeply committed to the arts, and we offer our sincere apology for the initial ads promoting our September 17 Teen Financial Education Day.
'They were intended to celebrate all the aspirations of young people and fell short of that goal. We are making changes to the campaign's creative that better reflect our company's core value of embracing diversity and inclusion, and our support of the arts. Last year, Wells Fargo's support of the arts, culture and education totalled $93 million.'