The classic Aussie phrase "no worries" also features in a conversation between a couple traversing the Andes in Chile.
Set to a modern take of I Still Call Australia Home, the video starts with a frequent Australian rite of passage as a young woman says farewell to her family at Melbourne Airport and ends with an off-duty Qantas pilot at Cottesloe Beach in Western Australia.
In between, about 20 Australians who are living in or visiting the destinations shown, explain lifejackets, emergency exits and why you should always ask for help if your phone slips between the seats.
Those featuring include a personal stylist in Tokyo, an actor in China and a translator in Chile.
The approach built on Qantas' recent safety videos that focused on Australian destinations.
Qantas International chief executive Alison Webster said the airline's safety video was a creative way to share the spirit of Australia with millions of customers every year.
"The primary purpose of these videos is to communicate an important safety message, and we know from our previous efforts that beautiful locations with a touch of humour is a great way to get people's attention each time they fly.
"This video lets us show off some of the amazing places you can travel on our network, and acts as a quick induction on Australian culture for visitors overseas about to fly here on a Qantas aircraft.
"We use real people, rather than actors, in our safety videos because it creates a sense of authenticity that's very Australian in itself."
Qantas worked with international and Australian state tourism organisations to make the film over five weeks. The new video will begin screening across Qantas domestic and international flights from April with different versions in 11 languages, as well as the varying aircraft types across the Qantas fleet.
The film is the latest in the non-traditional approach taken to safety videos by airlines. Air New Zealand was one of the pioneers but has faced pushback from plans to set its next one in Antarctica where one of its planes crashed in 1979 during a sightseeing flight.