The prospect of 20-hour, ultra-long-haul flights and how passengers will cope has provided impetus for a study of potentially tens of thousands of people.
The University of Sydney's Charles Perkins Centre will study Qantas customers using wearable technology to find out how they respond to being in planes.
Qantas chief customer officer Olivia Wirth said the airline's ambition of flying from the east coast of Australia to London and New York had added an additional level of research requirements around long haul flying.
"It's an exciting new frontier and we are eager to see how we can improve our understanding by taking a more scientific approach to the onboard experience of our passengers," she said.
Qantas and the centre have already worked together to influence cabin lighting, cabin temperature, meal timing and recipe development for the 787-9 Dreamliner which will fly the 17-hour Perth-London service from next March, as well as the design of the new transit lounge in the Western Australian city.
Professor Steve Simpson, academic director of the centre, said the research would be cutting edge and translated directly to help passengers and crew cope with the long range flights which the Australian airline and some other carriers are planning.
Aircraft manufacturers Boeing and Airbus are close to developing planes that, with a full load, would be capable of flying from Australian and New Zealand cities to destinations on the US east coast and Europe.