Its group chief commercial officer, John MacLeod said current circumstances demonstrated that Hong Kong was no longer a commercially viable route for his airline to keep operating.
"Hong Kong has continued to be a challenging market. With a decline in demand following ongoing civil unrest, and growing concerns over the
coronavirus outbreak in the wider region, we have made the decision to withdraw services.''
Virgin will re-deploy the aircraft across its existing network but hasn't announced what routes yet.
Cathay Pacific has been hard hit by months of pro-democracy protests leading to leadership changes at the top of the airline and now the coronavirus.
Yesterday it announced plans to cut 90 per cent of its flights into mainland China and reduce its total network capacity by 30 per cent in the next two months.
The airline is heavily reliant on travellers out of mainland China and the collapse of that market has forced it to ask staff to take unpaid leave for three weeks between March 1 and June 30.
The global airline industry has been rocked by the coronavirus with dozens of carriers, including Air New Zealand, abruptly pulling out mainland China.
The impact in China's massive domestic market has been marked with 27 per cent fewer aircraft flying this week compared to last week.