Boeing debuted a new, larger 787 Dreamliner on Friday in South Carolina.
The 787-10 is significant to Boeing as it tries to wipe away US$27.3 billion in losses that have existed since the Dreamliner programme began, Bloomberg reported.
Sales have slowed for larger twin-engine aircraft on international routes as cheaper fuel and similarly sized used Boeing 777s and Airbus Group SE A330s sap demand.
The 787-10's maiden flight is "a big, big milestone for us and our customers", chief executive Dennis Muilenburg said during a live webcast of the event.
"We're bringing innovation to the marketplace."