Although the airline has 8232 staff, Mr Fyfe said 193 job cuts had already been made since July, and 73 more would be achieved through not replacing staff yet to resign.
That would leave Air New Zealand having to lay off 175 more, mainly from management and support rather than front-line roles, and redundancy consultations had begun yesterday morning.
Mr Fyfe said that if more cuts were needed to improve the airline's annual profitability by $195 million by 2015, compared with just $38 million after tax reported yesterday, "we will be looking to use attrition wherever we can".
"A very difficult time for people when we have to envisage compulsory redundancies and that is certainly a last resort."
He said the job losses would not see an end to any "major functions" in the business.
"But we've looked at everything from all the reports we produce for example, saying do we need to produce all those reports [and] we're actually creating some new jobs.
"Net, we're losing jobs but we're looking at functions we currently outsource, whether it would be cheaper to bring those inside the company.
"Or likewise whether there are some things we do inside the company that we should look at outsourcing."
Mr Fyfe said the need for such deep cuts followed a doubling of the price of jet fuel over the past three years, in which the weak global economy was hindering Air New Zealand's ability to pass higher costs to passengers.
Airline chairman John Palmer reported solid business for its domestic operation helped by the Rugby World Cup and improved market share between New Zealand and Australia.
But he said the international long-haul network continued to face challenges in the European and Japanese travel markets.
Mr Fyfe said a review of long-haul flights, in which he has previously refused to rule out withdrawing the airline's flagship daily services to London, was nearing completion.
He expected to make announcements about the review in coming weeks, as it focused on strengthening its Pacific Rim network.
Air New Zealand this week announced it would begin its first international flights to Queensland's Sunshine Coast this winter in alliance with Virgin Australia, and that it would operate a twice-weekly service to Bali from June to October.
Mr Fyfe also yesterday announced the airline's first foray into South America, in the form of a charter flight in September to take the All Blacks and their fans to Argentina.