AirlineRatings.com said the high number of deaths came despite the number of accidents for 2014 being at a record low 21 - one for every 1.3 million flights.
"Two of the crashes last year - MH370 and MH17 - were unprecedented in modern times and claimed 537 lives," the report says.
"Flashback 50 years and there were a staggering 87 crashes killing 1,597 when airlines carried only 141 million passengers - five per cent of today's number."
Qantas, which AirlineRatings.com said was now also accepted as the world's most experienced airline, was praised as the leader in terms of real-time monitoring of its engines across its fleet using satellite communications.
"Doing so allows the airline to detect problems before they become a major safety issue," the report says.
Making up the remainder of the top 10 in alphabetical order were Air New Zealand, British Airways, Cathay Pacific, Emirates, Etihad Airways, EVA Air, Finnair, Lufthansa and Singapore Airlines.
AirlineRatings.com's rating system takes into account a range of factors related to audits from aviations governing bodies as well as government audits and the airlines fatality record.
Qantas, which has a fatality-free record in the jet era, was described as a leader in the development of an avionics system that provides a direct data link communication between the pilot and the air traffic controller, as well as the development of flight data recorders to monitor plane and crew performance.
The report rates 449 airlines, including low-cost carriers, with Jetstar making the top 10 of the later group.
The top 10 low-cost carriers in alphabetical order were Aer Lingus, Alaska Airlines, Icelandair, Jetstar, Jetblue, Kulula.com, Monarch Airlines, Thomas Cook, TUI Fly and Westjet.
- AAP
