Some of these patients had first been through the emergency department.
Mrs Wilkie said the numbers were unusual, as normally the team only saw one patient per week with synthetic drug-related issues.
She said some of the patients could be agitated, violent and can take a lot of time to treat.
"We expect to see presentations from people suffering withdrawal from synthetic cannabis in the coming weeks and months," she said.
Alcohol and drug counselling agency Te Utuhina Manaakitanga Trust has also had a number of people come to them for support after the law change.
Clinical manager Donna Blair said she advised anybody having trouble to contact the trust, another addiction counselling service, or see their GP.
A Rotorua ex-synthetic cannabis user, who did not want to be named, said he understood why some people had been suffering from withdrawal from the drug.
"I started taking synthetic highs thinking 'seeing as it's legal it must be safe'. But they weren't. Being on them - it was a weird, uncomfortable feeling and made me feel sick, disoriented, light-headed, but it was really addictive so I kept taking them," he said. "It took me ages to stop, and even longer for a friend of mine. When he stopped he became really depressed so I can see how hard it might be for people coming off them. It's terrible stuff."
Rotorua police alcohol harm reduction supervisor Sergeant Mike Membery said the four city outlets that had stocked synthetic drugs had been provided with leaflets from the health board to give to ex-users who may need help.
All had been complying with the new regulations and were sending their stock back to wholesalers, he said.
