In the locking department, Mitch Brown comes into start after Canadian standout Tyler Ardron came down with an infection this week. In the backline, Sean Wainui has an ankle injury, forcing a shift to combinations, Solomon Alaimalo going into left wing while Shaun Stevenson slots into the right.
Damian McKenzie also returns to action after his rest week, and Atu Moli is also back from injury to come off the bench.
It's an important fixture for the Chiefs who want to keep momentum alive but also make amends for the last time they played in front of their home fans.
A win would see them remain at the pointy end of the New Zealand conference and overall ladder, but a loss could see Gatland's men drop to third in their conference, sitting behind the Crusaders and Blues, should they both win their respective games, heading into two matches on the trot in South Africa.
Weber says that whilst the Chiefs always strive to win all their games, winning the intense New Zealand-derby matches almost feels like getting double points.
"We are trying to win everything, especially against New Zealand conference teams because it's almost worth double points and we know how important positioning is on the table down towards the latter end of the competition".
• Michael Pulman is a freelance journalist based in Hamilton
The Chiefs squad to play the Hurricanes
1. Aidan Ross
2. Samisoni Taukeiaho 3. Ross Geldenhuys
4. Michael Allardice
5. Mitchell Brown
6. Lachlan Boshier
7. Sam Cane
8. Pita Gus Sowakula
9. Brad Weber
10. Aaron Cruden
11. Solomon Alaimalo
12. Anton Lienert-Brown
13. Tumua Manu
14. Shaun Stevenson
15. Damian McKenzie
Reserves
16. Bradley Slater
17. Atu Moli
18. Reuben O'Neill
19. Naitoa Ah Kuoi
20. Mitchell Karpik
21. Lisati Milo-Harris
22. Kaleb Trask
23. Alex Nankivell
• Gallagher Chiefs vs Hurricanes, Friday March 13, 7.05pm at FMG Stadium Waikato, Hamilton
Gates Open: 4.15pm
• Curtain raisers: Chiefs Development vs Hurricanes Hunters, FMG Stadium Waikato, Friday March 13, 4.25pm.
•Tickets: www.chiefs.co.nz/game-tickets or from the ticketing office on Friday at Gate 1 at FMG Stadium Waikato. To celebrate 25 years, a special $25 ticket bundle is on offer for an adult and child ticket in the family uncovered or goal line zones.