Emergency services were called to the crash at the intersection of State Highway 47/SH4 about 7.30am.
Emergency services are at a crash involving multiple vehicles including a truck at National Park.
A police spokesman said they were called to the crash at the intersection of State Highway 47/SH4 about 7.30am and the road was partially blocked.
The crash involved a truck and two vehicles, he said.
A Hato Hone St John spokesperson said two people, one in a minor condition and one in a moderate condition, were taken to Taumarunui Hospital.
Another person in a minor to moderate condition was assessed and treated at the scene.
A Fire and Emergency NZ spokesman said two appliances from National Park and Ōwhango were at the scene.
No people were trapped, he said.
The route is currently a detour for the Desert Rd Tūrangi to Waiōuru road maintenance closure.
Police said support services will be available for those first on the scene.