"I think anyone that's been there knows that the scenery is actually surreal - it's so beautiful it's surreal and we hear that all the time."
Aside from Queenstown, Wanaka and Te Anau were singled out for special mention in the Southern Lakes entry.
Bennett said although Wanaka often felt "a little bit like a poor cousin", it offered a lot of the same charm as Queenstown on a smaller, quieter scale.
It is also the gateway to Mount Aspiring National Park, a place Bennett described as "paradise".
"Once you've been to that area, to the Southern Lakes, it could ruin you for travel for the rest of your life."
Tony Everitt, CEO of Destination Queenstown, said featuring in Best in Travel 2012 would bring significant benefits for the region's profile.
"To receive this kind of endorsement by Lonely Planet is priceless for Queenstown and the Southern Lakes as well as New Zealand," he said.
"Lonely Planet is a giant of the travel industry so making it onto their top 10 must-visit regions for 2012 will give our region global recognition and provide inspiration for their readers to visit."
The guide's top country to visit next year is Uganda, a place Bennett said was an "emerging tourist destination".
"People think of Uganda [and] they think of civil war and they think of Idi Amin and those are two reasons not to travel to a country, for sure, but that era is over...
"The actual trouble in Uganda is in very small pockets and very defined areas and for the most part, they're welcoming tourists. They've got the infrastructure but it's still at an early stage."
Bennett said Uganda would particularly appeal to travellers seeking an intrepid safari adventure.
London was named the top city to visit next year and the northeast of the United States was deemed the best-value destination.
LONELY PLANET'S TOP TRAVEL PICKS FOR 2012
Best regions
1. Coastal Wales
2. La Ruta Maya, Central America
3. Northern Kenya
4. Arunachal Pradesh, India
5. Hvar, Croatia
6. Sicily, Italy
7. Canada's Maritime Provinces (New Brunswick, Nova Scotia and Prince Edward Island)
8. Queenstown and Southern Lakes, New Zealand
9. Borneo, Brunei, Indonesia and Malaysia
10. Poitou-Charentes, France
Best cities
1. London, England
2. Muscat, Oman
3. Bengaluru (Bangalore), India
4. Cádiz, Spain
5. Stockholm, Sweden
6. Guimarães, Portugal
7. Santiago, Chile
8. Hong Kong, China
9. Orlando, Florida, USA
10. Darwin, Australia
Best countries
1. Uganda
2. Myanmar
3. Ukraine
4. Jordan
5. Denmark
6. Bhutan
7. Cuba
8. New Caledonia
9. Taiwan
10. Switzerland