Southbound lanes, from Munro St to 22nd Ave will be closed for approximately 15 minutes to allow the protest march to cross in order to get to Tauranga Girls' College.
Primary and secondary school teachers across New Zealand voted earlier this month to strike on May 29 for better pay and work conditions. In the Bay of Plenty, 148 schools will shut their doors - the second highest number in the country.
However, the Government's offer of $1.2 billion over four years is not expected to budge.
Education Minister Chris Hipkins said the offer would bring teachers into the top 20 per cent of income earners.
The industrial action is expected to be the largest strike by teachers and first ever combined teachers' strike, with 50,000 nationwide expected on the picket lines.
About 800,000 students are expected to be affected.
New Zealand Educational Institute (NZEI) Tauranga representative Andrea Andresen said this would be the "biggest strike this country has ever seen".
Andresen said she hoped the marches would communicate loud and clear to the Government they were serious and had a lot of support.
Ministry of Education deputy secretary for early learning and student achievement Ellen MacGregor-Reid said striking over $1.2b in pay offers did not offer a solution but instead would cause disruption to the learning of thousands of young people.
The Ministry offered both unions pay rises of three per cent a year for three years, taking the total pay rise for a majority of teachers to 12.6 per cent over three years.
Timeline of the strike
11.30am - Teachers will gather near the Tauranga racecourse for pre-march activities, including balloon blowing and message writing.
12pm - Speakers will address the crowds.
12.30pm - The march will begin on Chadwick Rd before turning on to Cameron Rd in the northbound lane. Teachers will be dropping messages off at MPs' offices on the way.
1.30/2pm - The march will wrap up as teachers reach Tauranga Girls' College.