Three people have been taken to Whanganui Hospital following a head-on crash on State Highway 1 at Utiku, south of Taihape.
A police spokesperson said police received a report of a collision at the intersection of SH1 and Rupe St around 9.15am on Wednesday.
A St John representative said three ambulances responded to the incident.
Staff treated and transported all three people involved in the crash to the hospital where they are in a moderate condition.
Fire and Emergency shift manager Jules Wevley said two Taihape fire crews responded to the accident.