State Highway 4 between National Park and Tohunga Junction is closed after a logging truck and trailer rolled.
Police were alerted to the crash at about 2:50 pm near Makatote Viaduct.
One person has moderate injuries and has been transported to Whanganui Hospital.
It is expected to take some time to clear the road, as heavy lifting equipment is required to move the truck.
Waka Kotahi says a detour is in place.