Taupo Quay is closed between the Whanganui City Bridge and St Hill St over concerns about loose iron on the fire-damaged Thain's building.
One lane of the bridge heading towards town and Victoria Ave between Ridgway St and Taupo Quay have also been closed by emergency services.
Loose iron on the roof of the building is flapping in the strong wind.
Meanwhile, Whanganui District Council has granted resource consent to demolish the building after it issued a demolition notice last week.
The building on the corner of Whanganui's Taupō Quay and Victoria Ave was extensively damaged by fire on July 20.