Seven people were transported to hospital on Sunday afternoon following a serious crash on State Highway 1 near Hunterville.
Emergency services were called to the scene that involved a truck and three cars.
A St Johns spokeswoman said five ambulances and a rescue helicopter were sent to the scene.
She confirmed that one person in a serious condition was airlifted to Palmerston North
Hospital while another person in serious condition was taken by ambulance.
A number of people were also transported to Whanganui Hospital by ambulance.