The Paramatta Eels have slumped to their fourth straight loss in the NRL, thumped 39-6 by Penrith at Paramatta Stadium.
The defeat is sure to pile more pressure on struggling coach Stephen Kearney with the Panthers running in seven tries to one.
Brisbane has rallied from 12-0 down to beat South Sydney 20-12 in Perth, but has lost star winger Jharal Yow Yeh to a serious ankle injury.