"Unfortunately, the ongoing effects of Covid meant that the 2020 event was unable to go ahead after being postponed twice so we're delighted to finally be able to welcome runners and their supporters back to the region," he said.
More than 4000 runners are set to head to the event for the first time, with more than 60 per cent of the sell-out crowd female.
The Hawke's Bay marathon has proved popular with runners from Auckland, with more than 30 per cent of entrants hailing from New Zealand's largest city, while more than 18 per cent are making the trip up from Wellington.
Local runners account for 17 per cent of entrants.
Hawke's Bay Tourism chief executive Hamish Saxton said the influx of athletes from outside the region would be valuable for our accommodation providers, eateries and retailers.
The Hawke's Bay marathon is a part of the Runaway Marathon Series, which includes the Queenstown Marathon and Runaway Noosa Marathon.