Frances, Cheryl and Teresa worked five days a week, supported by other part-time volunteers.
And there is an increasing need for the charity shop and its vast array of heavily discounted items.
"You see the need in people's faces, it's very difficult," Teresa said.
St Vincent de Paul is operated from Palmerston North and local conference president Bill Young said, "Organisations need to move with the times just to stay in business and in particular to comply with modern regulations."
Changing government regulations requiring greater accountability has meant the national organisation has created new structures for the shops to operate under with the requirement to use electronic tills, Eftpos and other systems to allow a charity shop such as Dannevirke's to remain in business.
But the resignation of so many staff has been devastating for Lyn Morris, a regular customer. For her, the store was more than a place to shop, it was where she found comfort, friendship and solace.
"You could go in feeling as grumpy as and come out with a big smile," she said.
"It's been a very special place for me and it's sad to see such a happy bunch leave. They were great ladies and a visit to Dannevirke's St Vincent de Paul's was the highlight of my three-weekly trip to town for so many years."
Gabrielle Schmidt, who had volunteered for eight years, said the team had shared plenty of laughs and it was great meeting people from all walks of life.
The charity shop opens again today, with a new team led by interim manager Frances Carthy.