Mad is well aware that her mother is depressed, and that they are both way outside what society expects from its women.
Elizabeth's story has it all, a traumatic childhood and a struggle against no ceiling, never mind a glass one. There's a beautiful integral love story with brilliant scientist Calvin Evans, and the tales of Elizabeth, Calvin and Mad are woven elegantly and knotted together tightly.
These three are the characters who win our hearts, but the peripheral team of Harriet (friend and babysitter), Miss Frask (nemesis), Walter (TV colleague) and Wakely (reverend and much more) serve the purpose of illustrating how humans don't have to cope alone, even when they feel cast out and at their lowest ebb.
Lessons in Chemistry is ostensibly a novel of a feminist thwarted by injustice, forced into taking on a role she doesn't want. But it's so much more than that. It provokes a whole gamut of emotion in the reader: fear, disgust, empathy, sadness and joy, and has many truly funny, inspiring moments. What a great read – I highly recommend it