They were all out of the vehicle when the emergency services arrived.
The Te Karaka Volunteer Fire Brigade attended, along with police and two ambulances.
Firefighters from Gisborne were also called out to the crash, but were recalled while they were on their way.
The highway was down to one lane at the scene for a time while the patients were tended to and the crash scene cleared.
Police have an inquiry under way.
■ The emergency services were called to the top of Panikau Hill on State Highway 35 at around 9.30am on Friday after a ute and car collided.
An emergency services spokesman said the people in one of the vehicles suffered some minor injuries.